We are interested in the ecological and evolutionary factors shaping bacteriophage genomes, and engineering phage genomes as tools for molecular biology.
We use laboratory work and bioinformatics to understand how different genomic parts of the virus affect the virus as a whole, their bacterial hosts, and the microbiomes they exist in.
We work by analyzing genomes in silico, synthesizing them in vitro, and generally dissecting and reassembling phages - specifically single-stranded DNA phages of the family Microviridae.
Currently, our focus lies on studying the interaction of microviruses with bacterial hosts and competition with other phages, as well as exploring microvirus diversity in humans and elsewhere.
In the future, we hope to leverage knowledge gained from this research into building customized phages for phage therapy and ecosystem engineering.
And Paul presents the newest research on mysterious marine mobile genetic elements
A new preprint in collaboration with Toni Luque from U. Miami describes our accidental discovery of a novel genetic element that looks suspiciously like a virus but does not resemble anything else...
Big News! Alex becomes the first graduate of the Kirchberger Lab - congratulations Master Chiconas! Also, Padam moves on from his short stint in the Kirchberger lab to start a postdoc at UNC Chapel...
A.K.A. the Howard Ochman & Nancy Moran Lab alumni reunion in lovely Austin Texas.